TPMS analysis of sacubitril/valsartan on macular degeneration
We used TPMS technology to model the response of sacubitril/valsartan drug combination on the proteins associated to heart failure (the indication) and macular degeneration (a common/recurrent adverse effect).
Download the input data and the models
The input data for the analysis, the models created using TPMS technology and the output results can be downloaded below.
Reproduce the results at SIMCELLS website
TPMS technology can be used to reproduce the results of the analysis by going to SIMCELLS website. For accession to the service, click on "Log in" and on "New registration" to facilitate your user name.
Input Protein Sets
Protein / Activation (+1 or -1) (.xlsx)Download
Models created using TPMS in MATLAB format (.ZIP)Download
GUILDify output for sacubitril/valsartan
Link of the results page of GUILDify v2.0 using as seeds the targets of sacubitril/valsartan.Link
GUILDify output for heart failure
Link of the results page of GUILDify v2.0 using as seeds the proteins associated with heart failure.Link
GUILDify output for macular degeneration
Link of the results page of GUILDify v2.0 using as seeds the targets of macular degeneration.Link